Thioredoxin Glutathione Reductase



Thioredoxin Glutathione Reductase (TGR) is an enzyme which bridges two detoxification pathways. It is composed of a small glutaredoxin domain at the N-terminal and a large thioredoxin reductase one at the C-terminal. The images at the left and at the right correspond to one representative TGR, i.e. the crystal structure of Thioredoxin Glutathione Reductase from Schistosoma mansoni (2v6o).

3D Structures of Thioredoxin Glutathione Reductase
2v6o, 2x8c, 2x8g, 2x8h – SmTGR+FAD – Schistosoma mansoni

2x99 - SmTGR+FAD+NADPH

3h4k - SmTGR+FAD+auranofin